Day 2 :
Keynote Forum
M Bonucci
University of Chieti, Italy
Keynote: Artoi nutritional approach in the hematological patient: Is there a rationale
Biography:
Massimo Bonucci MD is Chief of Clinical Pathology and Surgical Pathology and Outpatient Oncology in San Feliciano Hospital, Rome, Italy; he is a member of IAP (International Academy of Pathology-Italian Division). For ten years he had collaborative experience with Dr. Nieper (late President German Society of Oncology); after he introduced the use and development of integrative medicine on cancer patients in Italy. He is Professor of the G. Marconi University “Centro Studi Scienza Della vita” in Rome, for Master in Integrative Oncology of the postgraduate program. He is Professor on the University of Chieti for Master in Integrative Oncology of the postgraduate program for the year 2017-2019. He wrote a book “ Quello che mangi fa la differenza” who speaks about the integrative medicine and the nutrition. He organized from 2009 to 2018 the International meeting of Integrative Oncology in Rome. He is Visiting Professor at Zhejiang Chinese Medical University in Hongzhou, China.
Abstract:
Introduction: In the last years, it is emerging more and more convincingly the evidence that nutritional manipulation in oncological patients may have a therapeutic benefit. The principles which it is based on are as follows:
- Reducing sugar intake and growth factors (ex IGF1) to tumor cells
- Reducing the inflammatory pattern and the favorable ground to the development of the tumor cells
- Using foods with a proved antitumor protection because of their content of specific phytochemicals
Discussion: 1) The validity of the PET also in lymphomas and myelomas as well as the evidence of the glucose captation in bone marrow cells gives us that the reduction of sugar intake has a strong reason. Also, the role of IGF1 confirms that a reduced level of growth factors is important in this setting in the development of multiple myeloma cells. High levels of IGF1 are connected to an excessive intake of meat, cow cheese, and sugars, the last one through the action of insulin, which is a real growth factor for myeloma cells. In chronic lymphocytic leukemia, IGF1 is seen as a negative prognostic factor. (2) Reducing inflammation: in fact, many drugs used in hematology act on inflammatory pathways (ex Bortezomib). Therefore, it is of great relevance to eliminate foods well known as biomarkers of inflammation (C reactive protein and others) such as red meat and at the same time increasing those with proved anti-inflammatory power. Interference with NFkB, Bortezomib main function, is also documented for many substances such as turmeric that should be taken into account as useful therapeutic tools. (3) Activating a direct anticancer action: many substances studied for their cytostatic effects on hematological neoplastic cells, come from vegetable foods such as curcumin, epigallocatechin-3-gallate, and resveratrol.
Conclusions: It seems reasonable to use these substances in the patient’s diet to get at least an anti-inflammation response; for a real and effective anticancer action, we should make use of concentrated extracts following a specific therapeutic protocol.
Keynote Forum
Diana Anderson
University of Bradford, UK
Keynote: Sensitivity and specificity of the empirical lymphocyte genome sensitivity (LGS) assay: Implications for improving cancer diagnostics
Time : 09:55-10:35
Biography:
Diana Anderson holds the Established Chair in Biomedical Sciences at the University of Bradford. She obtained her first degree in the University of Wales and second degrees in the Faculty of Medicine, University of Manchester. She has 460+ peer-reviewed papers, 9 books, has successfully supervised 32 PhDs, is an Editorial Board Member of 10 international journals. She is Editor-in-Chief of a book series on Toxicology for the Royal Society of Chemistry. She gives keynote addresses at various international meetings. She is a consultant for many international organizations, including WHO, EU, NATO, TWAS, UNIDO, OECD.
Abstract:
Statement of the Problem: This study examined differences in the sensitivity to genomic damage of lymphocytes derived from cancer patients, pre/suspect cancer patients, and normal healthy volunteers. We investigated responses from 208 individuals: 20 melanoma, 34 colon cancer, 4 lung cancer patients (58); 18 suspect melanoma, 28 polyposes, 10 COPD patients (56) and 94 healthy volunteers. The natural logarithm of the Olive tail moment was plotted for exposure to UVA through 5 different agar depths (100 cell measurements/depth) and analyzed using a repeated measures regression model. Genomic damage in lymphocytes from cancer patient samples plateaued and did not decrease as UVA intensity decreased. In comparison, lymphocyte response patterns for healthy individuals returned towards control values as UVA intensity decreased. The responses for samples from pre/suspected cancers patients were intermediate. All cancers tested exhibited comparable responses. Results indicated that lymphocyte sensitivity was cancer status dependant, thus an analysis of Receiver Operating Characteristic curves was undertaken on 208 individuals. The mean log Olive tail moments, for all cancers plus pre/suspected-cancer versus controls gave a value for the area under the curve of 0.87 (95% CI: 0.82, 0.92); for cancer versus pre/suspected-cancer plus controls the value was 0.89 (95% CI: 0.83, 0.95); and for cancer alone versus controls alone (excluding pre/suspected-cancer), the value was 0093 (95%CI: 0.88, 0.98). For all 3 values p<0.001. Results indicated that the characterization of differences in lymphocyte sensitivity to UVA enabled discrimination between cancer patients, pre/suspect cancer patients, and healthy volunteers. This relationship could be used in an assay that functions as a stand-alone test or as a possible adjunct to other tests as part of a detection programme for cancer.
Keynote Forum
Andrew Jolivette
San Francisco State University, USA
Keynote: Examining Internal Traumatic Gay Men’s Syndrome (ITGMS) and syndemics among American Indian and indigenous gay men
Biography:
Andrew J Jolivette is Professor and former Chair of the Department of American Indian Studies at San Francisco State University, where he has been since 2001. He also currently serves as the Interim Executive Director of the San Francisco American Indian Community Cultural Center for the Arts. He is the author of five books: Among which Indian Blood: HIV and Colonial Trauma in San Francisco’s Two-Spirit Community was a finalist in the LGBTQ Studies Category for a Lambda Literary Award in June 2017. He recently served as scholar in residence in Native Sexualities and Public Health at the University of California, Santa Cruz in fall 2013. He is the former Vice-Chair of the Data Center: Research for Justice Board of Directors as well as a former board member with the African American Art and Culture Complex, the Vice-President for Finance for Black Community Matters and as a Board Member of the Center for Restorative Solutions in California. He is the Book Series Editor of Critical Indigenous and American Indian Studies at Peter Lang Publishing in New York.
Abstract:
Recent biomedical advances in HIV prevention strategies such as pre-exposure prophylaxis (PrEP) and achieving an undetectable viral load (UVL) support evidence-based scientific studies indicating HIV transmission rates can continue to be reduced through campaigns such as “Getting to Zero.” Despite the new evidence there continue to be disparities in risk and in access to prevention strategies based on a number of social, cultural, and economic factors collectively noted here as Syndemic impact (the co-constitutive epidemiological factors in large urban areas where the social and biological intersect). Syndemic impact when coupled with Internal Traumatic Gay Men’s Syndrome (the inter-generational, socially-isolating and traumatic [life changing] experiences that shape risk for HIV and overall long-term health outcomes for gay HIV positive men) can help to explain the on-going social and cultural impact of trauma on health outcomes for both negative and positive self-identified gay men. Previous studies (Diaz, 1997; Cohen, 1999; Vernon, 2001; Jolivette, 2016) have shown the socio-cultural and socio-psychological impact of identity factors such as race, religion, economic status etc. on the mental health of gay men of color. Among American Indians, First Nations, and Alaskan Native gay men we must also incorporate an analysis of (ITGMS) to explore how social and cultural interactions influence HIV prevention, treatment, and long-term care.
Keynote Forum
EE Enwereji
Abia State University, Nigeria
Keynote: Students’ sexual exposure in tertiary institutions: A case study of some universities in the Abia state of Nigeria
Biography:
EE Enwereji is an professor at College of Medicine, Abia State University Uturu, Nigeria. She teach medical, nursing and public health students and have attended several HIV and AIDS conferences both in the US and other places.
Abstract:
Introduction: Studies have shown that new entrants in institutions of higher learning are at risk of sexual exploits by the older students. The drama has been found to be an intervention strategy capable of internalizing both the emotional and cognitive dimensions of problems to produce positive changes. This study used drama to create awareness on likely common sexual exploits in institutions of higher learning. The study examined the extent to which students in tertiary institutions are at risk of multiple and same-sex sexual relationships.
Materials and method: The study used first-year students in three universities, Federal, State and Private. It was assumed that first year students in institutions of higher learning are likely to be exposed to sexual overtures by older students. As such, intervention to highlight this problem is needed. It was considered that using drama as an intervention will create awareness among the students on the types of sexual overtures they would possibly experience in tertiary institutions. A random sample of ninety ((90) students was used for the study. Thirty ((30) randomly selected students were used in each of the universities studied. Pre- and post-self-administered questionnaire were given to the selected students to complete. On completion, the copies of the questionnaire (pre- and post) were analyzed qualitatively and quantitatively.
Results: The study showed that students in these three universities studied were approached for sex by fellow students, but this was more at Rhema University 8 (28.8%) than in other universities. The students were, however, approached by both male and female sexes. The finding showed that some of the students in the three universities practiced anal, oral, and multiple sexes, but this was more in MOUA 10(33.3%) than in ABSU and Rhema with 9(30%) respectively. For knowledge on how HIV is transmitted, a good proportion of the students had the knowledge that HIV transmission occurs by sharing harp objects. This knowledge was more among students in MOUA 29 (97%) than among those in ABSU 28 (93%) and Rhema 27 (90%). On the method of HIV prevention, students in the three institutions studied claimed not aware of any method of HIV prevention, this claim was more among students in ABSU and Rhema with 19 (63%) respectively than in MOUA with 14 (47%).
Conclusion: Based on the result of the study, drama helped sexual risk behaviors that could predispose individuals to sexually transmitted infections including HIV. Drama, therefore, is a valuable and timely intervention strategy
- Hematology | Blood Disorders | Hemato-Oncology | Paediatric Hematology | Blood Banking | Hematology Nursing
Location: Plaza II
Session Introduction
Ogbonna Collins Nwabuko
Federal Medical Center, Nigeria
Title: Beyond the legislation for sickle cell prevention getting the right outcomes: A Nigerian experience
Biography:
Ogbonna Collins Nwabuko was born on the 12th of November, 1972. He hails from Umuode Nsulu in Isiala-Ngwa North Local Government Area of Abia State, Nigeria. He obtained his post-doctoral (FMCPath) fellowship in Hematology from the National Post-graduate Medical College of Nigeria in 2010. In 2012, he obtained a post-graduate certificate training in Palliative Medicine (PGCert.Pallia.Care) from the Institute for Hospice and Palliative Care in Africa, Kampala, Uganda. He is an international active member of American Society of Hematology, USA (ASH), a combined Master’s and PhD student of Public Health (Epidemiology) of University of South Wales (United Kingdom) and Walden University, Baltimore, USA respectively; a lecturer with Abia State University, and a consultant Hematologist with Federal Medical Center, Umuahia, Abia State, Nigeria. He is currently an editorial advisory board member of “The Open Orthopedics Journal”, Bentham Open; Cancer Management Research, Dove press, Journal of Blood & Lymph just to mention but a few.
Abstract:
Background: Sickle cell disease (SCD) is one of the non-communicable diseases (NCDs) of public health importance globally. It ranks among the top ten NCDs in Nigeria. The World Health Organization (WHO) considers it the most prevalent genetic disease in Africa. It is estimated that more than 300,000 births are affected annually worldwide and greater than 75% of the world’s SCD patients are said to be living in sub-Saharan Africa (CDC 2012). Nigeria ranks first in the sickle cell disease burden worldwide with 40 million people carrying the gene. It is reported to have one-third of the world’s annual incidence (i.e., 90-150 x 103 births annually (Piel et al., 2013). The estimated prevalence rate in Abia State, a south-eastern Nigerian state is 1.8% (Nwabuko et al., 2015). This is in keeping with the estimated national prevalence of 1-3%. A good health policy is the major determinant of the health of the population in any nation. Building healthy public policy is one of the major key factor areas of health promotion. It influences the health outcome of any nation with respect to average life expectancy and infant mortality rate (IMR). The United Nations and the WHO use the health outcomes of the population of a nation to rank the nation (CIA, n.d.). Nigeria ranks 214th (with average life expectancy from birth of 53.8 yrs) out of 224 member nations of the United Nations. The implication is that 213 countries in the world are healthier than Nigeria. Nigeria is the 8th worse country to be born on earth based on the IMR of 69.8 per 1000 live births per year (World Fact book, 2017). These poor health indices are attributable to lack of health-promoting policies from the government. Nigeria falls within the countries with the worst health policies and guidelines worldwide. The Abia State government, a state in south-eastern Nigeria, has just passed a bill for compulsory identification of blood groups and genotypes of all her citizens irrespective of their ages. This bill is a healthy public law which will authorize all health institutions in the state to craft policies that will curb the burden of SCD in the state by prevention, treatment, and curative interventions. For the first time, a state in Nigeria is holding the bull by the horn by promulgating a health-promoting policy which is geared towards preventing a disease of public health importance. A bill termed with the slogan “breaking the chains of SCD”. This study takes a look at this policy and how it can bring about the desired positive changes in the targeted audience and the entire population of the state. It also takes a look at the reproducibility and the challenges of implementing this health policy globally.
Niladri Shankar Ganguli
Calcutta School of Tropical Medicine, India
Title: Placental umbilical cord blood transfusion: A new method of treatment of patients with diabetes and microalbuminuria in the background of anemia
Biography:
Niladri Sankar Ganguli is a student of Regenerative Medicine and Translational Science (Part II), School of Tropical Medicine Kolkata. He is presently working under Prof Niranjan Bhattacharya, HOD of Regenerative Medicine and Translational Science, School of Tropical Medicine, Kolkata. His special interest is in Cord Blood Banking, its transfusion affect in various diseases including Malignancy. He passed MBBS in the year 1980 from North Bengal Medical College and was a senior resident in the Dept of Orthopedic Surgery SSKM hospital Kolkata and a junior resident in the Dept of Obstetrics and Gynecology in the same hospital. He is a practicing physician since last 35 years.
Abstract:
Diabetes mellitus is the commonest endocrine disease in all populations and all age groups. It is a syndrome of disturbed intermediary metabolism caused by inadequate insulin secretion or impaired insulin action, or both. Anemia is a common accompaniment of diabetes, particularly in those with albuminuria justifying tubulointerstitial injury or reduced renal function. There are other additional factors present in diabetes, which may contribute to the development of an increased risk of anemia. Cord blood, because of its rich mix of fetal and adult hemoglobin, high platelet and WBC counts, hypo-antigenic nature, altered metabolic profile and high affinity for oxygen, may be an ideal choice for cases of diabetes with severe anemia necessitating blood transfusion. This article presents my team's experience with 78 units of placental umbilical cord whole blood (from 1 April 1999 to April 2005), collected after lower uterine cesarean section (LUCS) from consenting mothers (56 ml-138 ml mean 82ml+/-5.6ml SD, median 84ml, mean packed cell volume 49.7+/-4.2 SD, mean percent hemoglobin concentration 16.6g/dl+/-1.5g/dl SD) and transfused to diabetes patients with microalbuminuria and severe anemia necessitating transfusion. After collection, the blood was transfused, in most cases immediately after completion of the essential norms of transfusion. In rare cases, it was kept in the refrigerator and transfused within 72 hours of collection to a suitable recipient. For inclusion in this study, the patient's percent plasma hemoglobin had to be 8g/dl or less (the pretransfusion hemoglobin in this series varied from 5.2g/dl to 7.8g/dl) in the background of type two diabetes (fasting sugar 200mg or more), along with features of microalbuminuria (albumin excretion 30-299mg/g creatinine). This study included 39 informed consenting patients (22 males+17 females, aged 48-74 yrs, mean 59.6 yrs). The patients were randomized into two groups: Group A (control cases N=15, males=8 and females=7) and Group B (study group N=24, males=14 and females=10). In Group A the rise of hemoglobin (Hgb) after two units of adult blood transfusion was 1.5 to 1.8g/dl, as seen after a 72-hour blood sample assessment. The rise of Hgb as noted after 72 hours of two units of freshly collected cord blood transfusion was 0.6g/dl to 1.5g/dl. Each patient received two of four units of freshly collected cord blood transfusion (two units at a time), depending on availability and compatibility. Microalbuminuria was assessed in both groups after one month of treatment with transfusion and other identical support. The mean result was 152+/-18m SD of albumin per gram of creatinine excreted through 24-hour urine (pre-transfusion mean excretion was 189+/-16mg) in Group A and 103+/-16mg SD of albumin excretion per gram of creatinine in 24-hour excretion of urine in Group B (pretransfusion mean excretion was 193+/-21mg). Univariate analysis using Fisher's exact test was performed for the results of Groups A and B. The difference between Group A and B values and its comparison with the pre-transfusion microalbuminuria appeared to be statistically significant (p< less than .003). We have not encountered any clinical, immunological or non-immunological reaction so far in either group. Fetomaternal cell traffic has been implicated as the cause of scleroderma in mothers delivering male babies. In the present series, we did not see any such rare and unusual complication due to neonatal blood transfusion in the adult system in Group B patients in the six years from the initiation of the study.