Sylvia Heloisa Arantes Cruz
University of Sao Paulo, Brazil
Title: Follow up on anal pap-smear in HIV-positive and negative patients
Biography
Biography: Sylvia Heloisa Arantes Cruz
Abstract
HPV infection is responsible for warts and carcinoma in genital area. Almost 80% of the sexual active population is infected with at least one serotype. The cervix Pap smear is collected for the prevention of the cervix cancer performing a similar technique we are able to prevent anal cancer collecting anal Pap-smear. The rates of anal cancer are increasing since the start of HIV epidemic. The anal intercourse seems to be extremely related to HPV infection. Anal dysplasia is described as a precursor of anal squamous carcinoma, so anal cancer has been screened with anal Pap-smear protocol, high-resolution anoscopy and high-risk HPV DNA test. The aim of this study is to compare the findings of the screening with anal Pap-smear in 38 HIV-positive and negative patients from January 2014 to December 2015 at CRT/AIDS, São Paulo who previously had anal intercourse. The first anal Pap-smear sample was collected in 2014 and the second in 2015. The anal lesions were treated with 90% trichloroacetic acid (TCA) and 5% imiquimod for 12 weeks. The statistical analysis was performed using chi-square test and the significance level was set at less than 5%. 38 patients were evaluated, 28 were infected with high risk HPV; 10 of them presented improvement in anal Pap-smear after one year. We concluded that anal dysplasia was more common in HIV-positive patients and that high-risk HPV infection was related to anal dysplasia.